That's pretty much what my KTM 1190 is. It does have a 19" front wheel and lots of people have converted them to 17" to make use of sports tyres. I've thought about it but TBH it handles so well I can't see the point. It's an absolute weapon that can be flung on its ear and sticks to the tarmac like glue. I've run Continental Road Attacks on it for years and can't fault them. If the Africa Twin is anything like the 1190 in handling I think you'll quickly forget about the 19" wheel.
But at 60,000 miles my 1190 is getting long in the tooth. It's also very heavy on chain maintenance. Partly because it's a big torquey V twin and they do eat chains and sprockets, and partly because it has a very long chain run. The standout feature of my Harley and Rocket 3 adventures was the blissful absence of chain maintenance.
I'll be interested to know how you get on with the AT. The V1000 Stelvio does seem to grab me for some reason. Not so much the TT85 as that engine is a bit breathless. The new V1000 mill is in a different league. I'd like to ride one. My only doubt is that I've heard they're not that roomy for taller riders. The KTM is a winner in that department. It's stupid tall, especially the way I've got it set up. At 6' tall I'm on absolute tip-toe but there masses of leg room on the move which means I can ride it for hours in comfort.
Now you mention wrist ache, that's something that's also starting to affect me. Well, more hands and fingers than wrist, as I think I'm becoming arthritic in my hands. The Streetfighter has a very heavy clutch. I reckon that will be a struggle when I finally get it back on the road. Even the 1190 causes some strain as it has a long lever stroke, even when adjusted to the minimum. Not sure I could get my head around the idea of auto transmission though. Be interesting to hear how the Honda system works out.